Curcumin has also been found to alleviate neuro-inflammation in a mouse model of traumatic brain injury, reducing macrophage and microglial activation and increasing neuronal survival.
A placebo-controlled trial in 40 men who had surgery to repair an inguinal hernia or hydrocele found that oral curcumin supplementation (1.2 g/day) for five days was more effective than placebo in reducing post-surgical edema, tenderness and pain, and was comparable to phenylbutazone therapy (300 mg/day).
This includes heart disease, cancer and a whole host of neurological disorders.
The high concentrations of curcumin contained in turmeric act to target multiple steps in the inflammatory pathway, blocking inflammatory markers at the molecular level and thereby significantly lowering long-term inflammation in your body.
And its no wonder considering six major scientific trials all found curcumin to possess a potent anti-inflammatory action, which is completely non-toxic in nature.
A study evaluating several pharmaceutical anti-inflammatories found that aspirin and ibuprofen are the potent, while curcumin is among the most potent anti-inflammatory and anti-proliferative agents available.
in 2012, postmenopausal women who took curcumin for eight weeks had an improvement in arterial function, comparable to that seen in women who engaged in aerobic exercise.
Studies looking at curcumins effects on cholesterol and other lipids have had inconsistent results.The spice worked as well as the drug, but without the negative side effects. Curcumin has also been shown to inhibit mediators of the inflammatory response, including cytokines, chemokines, adhesion molecules, growth factors, and enzymes like cyclooxygenase (COX), lipoxygenase (LOX), and inducible nitric oxide synthase (i NOS).Nuclear factor-kappa B (NF-κB) is a transcription factor that binds DNA and induces the transcription of the COX-2 gene, other pro-inflammatory genes, and genes involved in cell proliferation, adhesion, survival, and differentiation.Studies have shown that endothelial dysfunction is a common cause of heart disease, occurring when the endothelium is no longer able to regulate blood pressure, clotting and a number of other factors.Therefore, by improving endothelial function, curcumin lowers your risk of heart disease.In nature's never-ending interaction between predator and prey, insects evolve the ability to digest plant toxins, while plants evolve stronger chemicals to deter their enemies.